Portfolio
Published Works
2. Cobb SG, Tepe JJ. Recent advancements in 20S proteasome enhancement: degradation of undruggable targets. ACS Med Chem Lett. 2025;16(10):1896-1904. doi:10.1021/acsmedchemlett.5c00451
1. Cobb SG. Investigation into the Mechanism of Action Behind Small Molecule-Mediated Enhancement of the 20S Proteasome through the Development and Utilization of Novel Nitrogenous Heterocyclic Compounds. Dissertation. University of Virginia; 2025. doi:10.18130/cfc1-hz19
Editorial Portfolio
I've provided editorial support for several peer-reviewed publications and academic theses, which are listed chronologically.
9. Bloch JM, Savelson E, Meng AQ, et al. Tungsten-enabled Diels–Alder cycloaddition and cycloreversion of arenes and alkynes: divergent synthesis of highly functionalized barrelenes and arenes. J Am Chem Soc. 2025;147(33):30146-30153. doi:10.1021/jacs.5c08320
8. Savelson E, Selewski KA, Tepe JJ. A tetrazine-based synthesis for accessing underutilized aza-indole analogues. Chem Eur J. 2025;31(25):e202500751. doi:10.1002/chem.202500751
7. Dvorak KR. NITROGEN-CONTAINING HETEROCYCLES: THEIR APPLICATION IN TOTAL SYNTHESIS OF BIS- AND TRIS-INDOLE NATURAL PRODUCTS AND 20S PROTEASOME MODULATION. Master's thesis. Michigan State University; 2024. doi:10.25335/hk8w-6513 [Editorial support provided on Chapter 3 of the thesis]
6. Staerz SD, Anamoah C, Tepe JJ. 20S proteasome enhancers prevent cytotoxic tubulin polymerization-promoting protein induced α-synuclein aggregation. iScience. 2024;27(7):110166. doi:10.1016/j.isci.2024.110166
5. Dvorak KR, Tepe JJ. Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties. Nat Prod Rep. 2024;41:1264-1293. doi:10.1039/D4NP00012A
4. Staerz SD. DISCOVERY AND DESIGN OF NOVEL 20S PROTEASOME ACTIVATORS FOR TARGETED PROTEIN DEGRADATION AND THEIR EVALUATION IN NEURODEGENERATION MODELS. Dissertation. Michigan State University; 2024. doi:10.25335/rmr4-1w59
3. George DE, Tepe JJ. Total synthesis of nagelamide W. J Org Chem. 2023;88(13):9306-9312. doi:10.1021/acs.joc.3c00867
2. Savelson E, Tepe JJ. Accessing highly oxidized imidazolidinone cores via a Curtius rearrangement: total synthesis of colensolide A. Org Lett. 2023;25(20):3698-3701. doi:10.1021/acs.orglett.3c01139
1. Staerz SD, Lisabeth EM, Njomen E, Dexheimer TS, Neubig RR, Tepe JJ. Development of a cell-based AlphaLISA assay for high-throughput screening for small molecule proteasome modulators. ACS Omega. 2023;8(17):15650-15659. doi:10.1021/acsomega.3c01158